Turkish scorzonera species extracts attenuate cytokine secretion via inhibition of NF-κBactivation, showing anti-inflammatory effect in vitro

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dc.contributor.authorAcıkara, Özlem
dc.contributor.authorİşcan, Hayriye Gülçin Saltan
dc.contributor.authorSmejkal, Karel
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.date.accessioned2019-06-27T13:20:17Z
dc.date.available2019-06-27T13:20:17Z
dc.date.issued2016
dc.description.abstractScorzonera species are used in different folk medicines to combat many diseases, including the illnesses connected with inflammation. Previous experiments showed anti-inflammatory activity of Scorzonera extracts in vivo. S. latifolia, S. cana var. jacquiniana, S. tomentosa, S. mollis ssp. szowitsii, S. eriophora, S. incisa, S. cinerea, and S. parviflora extracts were, therefore, evaluated for their inhibitory activities of TNF- and IL-1 production, and NF-B nuclear translocation in THP-1 macrophages. The HPLC analysis was carried out to elucidate and to compare the composition of these extracts. Major compounds of the tested extracts have been isolated using different chromatographic techniques and further tested for their inhibitory activities on TNF- and IL-1 production. Several extracts showed promising anti-inflammatory activity in these in vitro tests. Results of HPLC analysis revealed chlorogenic acid as a compound present in all tested extracts. Hyperoside, quercetin-3-O--d-glucoside and rutin were also present in varying amount in some Scorzonera species analyzed. Furthermore, eight phenolics which were identified as quercetin-3-O--d-glucoside (1), hyperoside (2), hydrangenol-8-O-glucoside (3), swertisin (4), 7-methylisoorientin (5), 4,5-O-dicaffeoyl-quinic acid (6), 3,5-di-O-caffeoyl-quinic acid (7), and chlorogenic acid (8) have been isolated as major phenolic compounds of the tested extracts and, together with eight terpenoids (9-16) previously obtained from different Scorzonera species, have been tested for the inhibition of TNF- production, unfortunately with no activity comparable with standard.tr_TR
dc.description.indexScopus
dc.description.indexWos
dc.description.indexwos
dc.identifier.endpage14tr_TR
dc.identifier.issue01tr_TR
dc.identifier.other10.3390/molecules21010043
dc.identifier.startpage01tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/66843
dc.identifier.volume21tr_TR
dc.language.isoentr_TR
dc.relation.journalMoleculestr_TR
dc.subjectAnti-inflammatory activitytr_TR
dc.subjectIL-1tr_TR
dc.subjectNF-Btr_TR
dc.subjectScorzoneratr_TR
dc.subjectPhenolictr_TR
dc.titleTurkish scorzonera species extracts attenuate cytokine secretion via inhibition of NF-κBactivation, showing anti-inflammatory effect in vitrotr_TR
dc.typeArticletr_TR

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